Frequently Asked Questions

GLP-1 (glucagon-like peptide-1) is a hormone your body naturally produces that helps regulate blood sugar and appetite. GLP-1 receptor agonist medications mimic this hormone, helping you feel fuller longer and reducing food cravings. The two most common GLP-1 medications are semaglutide (the active ingredient in Ozempic and Wegovy) and tirzepatide (the active ingredient in Mounjaro and Zepbound).

GLP-1 agonists bind to GLP-1 receptors in your brain and gut. They slow stomach emptying so you feel full longer, reduce appetite signals in the brain, and help regulate blood sugar levels. Tirzepatide also targets GIP receptors, which may provide additional metabolic benefits. These medications are typically injected once weekly, though some newer formulations are available as oral tablets or drops.

GLP-1 medications have been studied extensively in large clinical trials and are FDA-approved for weight management (Wegovy, Zepbound) and type 2 diabetes (Ozempic, Mounjaro). Common side effects include nausea, diarrhea, and constipation, which often improve over time. More serious but rare side effects can occur. Always consult your doctor to determine if these medications are appropriate for you, especially if you have a history of thyroid issues, pancreatitis, or gallbladder problems.

Brand-name GLP-1s (like Ozempic and Mounjaro) are manufactured by large pharmaceutical companies and can cost $1,000+ per month without insurance. Compounded versions contain the same active ingredients but are prepared by compounding pharmacies, often at significantly lower prices. The FDA allows compounding when brand-name drugs are in shortage. The providers listed on GLP321.com primarily offer compounded versions through licensed telehealth platforms.

Coverage varies widely. Many insurance plans cover GLP-1s for type 2 diabetes but not for weight loss alone. Some plans are starting to cover weight management indications, but often with prior authorization requirements and step therapy. Medicare currently does not cover GLP-1s for weight loss, though legislation to change this is being considered. The compounded GLP-1 providers on our site are typically cash-pay, making them a more affordable option for those without coverage.

Most people start noticing reduced appetite within the first few weeks. Clinical trials show average weight loss of 5-10% of body weight within the first 3 months, with continued progress over 12-18 months. Tirzepatide trials have shown average weight loss of up to 22% of body weight. Results vary significantly between individuals based on dosage, diet, exercise, and other factors.

Many telehealth providers now offer GLP-1 prescriptions through online consultations. The typical process involves completing a health questionnaire, having a virtual consultation with a licensed provider, and receiving your medication by mail. Our comparison table helps you evaluate these providers based on price, medication type, and other factors. Always ensure the provider is licensed in your state.

If you already have a GLP-1 prescription from your doctor, some telehealth providers can fulfill it at a lower cost than traditional pharmacies. However, most compounded medication providers require their own consultation since compounded formulations differ from brand-name products. Check with individual providers about whether they accept outside prescriptions.

The cost per milligram ($/mg) is the most fair way to compare providers because different providers offer different doses. A provider charging $200/month for 10mg per week is actually cheaper per milligram than one charging $150/month for 5mg per week. We use $/mg as the default sort so you can make true apples-to-apples comparisons regardless of dosage.

Currently, we don't. GLP321.com is an independent project built to help consumers find affordable GLP-1 medications. We do not use affiliate links, accept payment from providers, or allow sponsored placements. Rankings are based purely on data, and that will never change.

We verify pricing data regularly, but telehealth providers frequently change their pricing and offers. Each provider listing includes a 'last verified' date. If you notice outdated or incorrect information, please use our Report Incorrect Data form to let us know and we'll update it promptly.

No. GLP321.com is completely independent. We are not affiliated with, sponsored by, or partnered with any telehealth provider, pharmaceutical company, or pharmacy listed on this site. Our only goal is to provide neutral, data-driven comparisons to help consumers make informed decisions.